Each mouth dissolving tablet contains: Clonazepam 0.25/0.50/1 mg respectively.
Clonazepam is a benzodiazepine drug having anxiolytic, anticonvulsant, muscle relaxant, and hypnotic properties.
Clonazepam exerts its action by binding to the benzodiazepine site of the GABA receptors, which causes an enhancement
of the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons.
This results in an inhibition of synaptic transmission across the central nervous system. Benzodiazepines, however, do
not have any effect on the levels of GABA in the brain. Clonazepam has no effect on GABA levels and has no effect on
gamma-aminobutyric acid transaminase. Clonazepam does however affect glutamate decarboxylase activity. Benzodiazepine
receptors are found in the central nervous system but are also found in a wide range of peripheral tissues such as
longitudinal smooth muscle-myenteric plexus layer, lung, liver and kidney as well as mast cells, platelets, lymphocytes,
heart and numerous neuronal and non-neuronal cell lines.
INDICATIONS
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behavior,
such as pacing back and forth, somatic complaints, and rumination. It is the subjectively unpleasant feelings of dread over
anticipated events. Anxiety is not the same as fear, which is a response to a real or perceived immediate threat, whereas
anxiety is the expectation of future threat.
Seizures An epileptic seizure, occasionally referred to as a fit, is defined as a transient symptom of "abnormal
excessive or synchronous neuronal activity in the brain".
Unipolar Depression Major depressive disorder (MDD) (also known as recurrent depressive disorder, clinical depression,
major depression, unipolar depression, or unipolar disorder) is a mental disorder characterized by an all-encompassing low
mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.
NOTE
P value is used to determine whether the results are statistically significant. P-values are often used in hypothesis
tests, where you either reject or fail to reject a null hypothesis. When you do a hypothesis test, the key piece of output to
concentrate on is the p-value. A p-value ranges from 0 to 1. The p-value is a probability that measures the evidence against
the null hypothesis. Lower probabilities provide stronger evidence against the null hypothesis.
Panic Disorder is an anxiety disorder characterized by recurrent unexpected panic attacks. Panic attacks are sudden
periods of intense fear that may include palpitations, sweating, shaking, shortness of breath, numbness, or a feeling that
something really bad is going to happen. Tapering mean diminish or reduce.
Tapering mean diminish or reduce.
Temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals.
Partial (focal) epilepsies are seizures which affect initially only one hemisphere of the brain.
DOSE
Once daily one or two tablets or as directed by the doctor.
INTRODUCTION
Each mouth dissolving tablet contains: Clonazepam 0.25/0.50/1 mg respectively.
Clonazepam is a benzodiazepine drug having anxiolytic, anticonvulsant, muscle relaxant, and hypnotic properties. Clonazepam exerts its action by binding to the benzodiazepine site of the GABA receptors, which causes an enhancement of the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons. This results in an inhibition of synaptic transmission across the central nervous system. Benzodiazepines, however, do not have any effect on the levels of GABA in the brain. Clonazepam has no effect on GABA levels and has no effect on gamma-aminobutyric acid transaminase. Clonazepam does however affect glutamate decarboxylase activity. Benzodiazepine receptors are found in the central nervous system but are also found in a wide range of peripheral tissues such as longitudinal smooth muscle-myenteric plexus layer, lung, liver and kidney as well as mast cells, platelets, lymphocytes, heart and numerous neuronal and non-neuronal cell lines.
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behavior, such as pacing back and forth, somatic complaints, and rumination. It is the subjectively unpleasant feelings of dread over anticipated events. Anxiety is not the same as fear, which is a response to a real or perceived immediate threat, whereas anxiety is the expectation of future threat.
Seizures An epileptic seizure, occasionally referred to as a fit, is defined as a transient symptom of "abnormal excessive or synchronous neuronal activity in the brain".
Unipolar Depression Major depressive disorder (MDD) (also known as recurrent depressive disorder, clinical depression, major depression, unipolar depression, or unipolar disorder) is a mental disorder characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.
P value is used to determine whether the results are statistically significant. P-values are often used in hypothesis tests, where you either reject or fail to reject a null hypothesis. When you do a hypothesis test, the key piece of output to concentrate on is the p-value. A p-value ranges from 0 to 1. The p-value is a probability that measures the evidence against the null hypothesis. Lower probabilities provide stronger evidence against the null hypothesis.
Panic Disorder is an anxiety disorder characterized by recurrent unexpected panic attacks. Panic attacks are sudden periods of intense fear that may include palpitations, sweating, shaking, shortness of breath, numbness, or a feeling that something really bad is going to happen. Tapering mean diminish or reduce.
Tapering mean diminish or reduce.
Temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals.
Partial (focal) epilepsies are seizures which affect initially only one hemisphere of the brain.
Once daily one or two tablets or as directed by the doctor.