INJ: METHYLCOBALAMIN IP 1500MCG. BENZYL ALCOHO IP 2% V/V (AS PRESERVATIVE) WATER FOR INJECTION IP Q.S.
Carbohydrates are chemically made up of carbon, hydrogen and oxygen to form sachhharide groups like mono, di and
poly. Carbohydrates are absorbed as monosaccharides as glucose.Fructose and galactose are also converted to glucose.
Proteins are made up of amino acids in which is essential for nutrition, growth and repair. Absorbed into blood.
Proteins cannot be stored, excess protein converted to carbohydrate and fat. 23 amino acids are there 10 are essential.
Fat are fuel supply of animal kingdom. Body depot fats are mainly composed of triglycerides which are ester of
fatty acid and glycerol.
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from cyanocobalamin
in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral cobalt(III) centre
and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to vitamin B12, and can be used
to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy, diabetic neuropathy, and as a
preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and differs from cyanocobalamin in
that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some bacteria. It plays an important role
in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin plays an important role in
transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin is well transported to nerve
cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin, prescribed for peripheral
neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. Peripheral neuropathies-
the recommended dose is 1,500 mcg/day in 3 divided doses.
Folic acid is essential for normal erythropoiesis process by exogenous administration. Folic acid is vital for the
biosynthesis of purines and thymidylate of nucleic acids. Folic acid is rapidly absorbed in the proximal portion of the
small intestine. After oral administration, the Cmax can be achieved within one hour. Folic acid is well-distributed in
all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into dihydrofolate and
tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine.
Lycopene is a bright red carotene and carotenoid pigment and phytochemical found in tomatoes and other red fruits and
vegetables. Although lycopene is chemically a carotene, it has no vitamin A activity. Lycopene is not an essential nutrient
for humans, but is commonly found in the diet, mainly from dishes prepared from tomatoes. When absorbed from the stomach,
lycopene is transported in the blood by various lipoproteins and accumulates in the liver, adrenal glands, and testes.
Because preliminary research has shown an inverse correlation between consumption of tomatoes and cancer risk, lycopene has
been considered a potential agent for prevention of some types of cancers, particularly prostate cancer.
Spirulina Spirulina is a cyanobacterium (blue-green algae) that can be consumed by humans and other animals. There are
two species, Arthrospira platensis and Arthrospira maxima. Arthrospira is cultivated worldwide; used as a dietary supplement
as well as a whole food; and is also available in tablet, flake and powder form. It is also used as a feed supplement in the
aquaculture, aquarium and poultry industries.
Lutein is a xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and
like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. In
green plants, xanthophylls act to modulate light energy and serve as non-photochemical quenching agents to deal with triplet
chlorophyll (an excited form of chlorophyll), which is overproduced at very high light levels, during photosynthesis.
Potassium sulphate forms alkaline salts that are important in body processes and play an essential role in maintenance
of the acid base and water balance in the body.
Vitamins- Water Soluble – B Complex & C, Fat Soluble – A,D,E & K.
VitB1 or thaiamine requirement is 1-2 mg and Defficiency causes Beriberi.
VitB2 or Riboflavin requirement is 1.5-3 mg and Defficiency causes Angular Stomatitis, Glossitis, magenta
colour of tongue.
VitB6 is Pyridoxin requirement is 1-2 mg and Deficiency causes Pellagra.
VitB12 is Cyanocobalamin requirement is 1 mcg and Deficiency causes ineffective haemopoiesis, Generalised debility.
It is a water soluble B vitamin. The mechanism of action is straightforward: the hydroxycobalamin hydroxide ligand is
displaced by the toxic cyanide ion, and the resulting harmless B12 complex is excreted in urine.B12 is also known as
cobalamin because it contains cobalt. B12 is only produced by bacteria. So it is only found in food products of animal
origin and in some fermented vegetable products. B12 works closely with another B vitamin, Folic acid in reactions
involved with DNA synthesis, blood cell formation, nervous sytem formation and heart health.
Nicotinamide(Niacinamide) or PPF requirement is 15-20 mg and Deficiency causes Pellagra(Dermatitis & Pigmentation of skin).
Calcium D-Panothenate is calcium salt of pantothenic acid. Pantothenic acid, also called vitamin B5 (a B vitamin), is
a water-soluble vitamin. Pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A
(CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. The anion is called pantothenate.
Chromium(III) picolinate is a chemical compound sold as a nutritional supplement to treat type 2 diabetes and promote
weight loss. This bright-red coordination compound is derived from chromium(III) and picolinic acid. Small quantities of
chromium are needed for glucose utilization by insulin in normal health, but deficiency is extremely rare and has only been
observed in hospital patients on long-term defined diets. Chromium has been identified to regulate insulin by increasing the
sensitivity of the insulin receptor. As such, chromium(III) picolinate has been used as a treatment for type 2 diabetes.
VitA is Retinol requirement is 5000 I.U. and deficiency causes Nyctalopia(blindness).
VitE is Alpha Tocoferol and deficiency causes not known till date.
VitC is Ascorbic acid and deficiency causes Scurvy.
Zinc Zinc is an essential mineral. In children it causes growth retardation, delayed sexual maturation, infection
susceptibility, and diarrhea. Zinc stimulates the activity of about 200 enzymes, maintain healthy immune system, maintains
memory, prevents premature delivery, helps AIDS patients to increase immunity, has anti-inflammatory benefits , needed for
DNA synthesis , helps normal growth and development, helps sperm production and ovulation, helps in digestion of food,
prevents hair loss and Alopecia, provides healthy nails, strengthen bone, helps to fight infection, helps in controlling
diabetes, helps acne and wound healing, is vital in protein stnthesis, helps in carrying cabon-di-oxide from the cells.
Zinc requirements Infants- 0 - 6 months: 2 milligrams per day (mg/day), 7 - 12 months: 3 mg/day /, Children: 1 - 3 years:
3 mg/day, 4 - 8 years: 5 mg/day, 9 - 13 years: 8 mg/day /Adolescents and Adults - Males age 14 and over: 11 mg/day, Females
age 14 to 18 years: 9 mg/day, Females age 19 and over: 8 mg/day.
Copper daily requirement is 2 mg and deficiency not known.
Manganese is required for enzymatic activity and cholesterol synthesis.
Selenium reduces the effects of vit E deficiency, particularly liver necrosis and muscular dystrophy.
INDICATIONS
Diabetic neuropathies are nerve damaging disorders associated with diabetes mellitus. These conditions are thought
to result from diabetic microvascular injury involving small blood vessels that supply nerves in addition to macrovascular
conditions that can culminate in diabetic neuropathy.
NOTE
Antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that
transfers electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce free radicals.
In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death
to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation
reactions. They do this by being oxidized themselves.
Essential vitamins is a nutrient required for normal physiological function that cannot be synthesized by the body,
and thus must be obtained from a dietary source.
Minerals Minerals are inorganic substances playing important role in body mechanism – sodium, potassium, iron,
phosphorus, magnesium and sulphur.
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with
no apparent physical cause.
Myelination is the production of the myelin sheath. Myelin is a fatty white substance that surrounds the axon of some
nerve cells, forming an electrically insulating layer. It is essential for the proper functioning of the nervous system.
Homocystein is a non-protein α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional
methylene bridge (-CH2-). Homocysteine can be recycled into methionine or converted into cysteine with the aid of certain
B-vitamins. A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell
injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in
ischemic injury.
Omega-3 fatty acids are of three types involved in human physiology are α-linolenic acid (ALA) (found in plant oils),
eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) (both commonly found in marine oils). Marine algae and phytoplankton
are primary sources of omega-3 fatty acids. Common sources of plant oils containing the omega-3 ALA fatty acid include walnut,
edible seeds, clary sage seed oil, algal oil, flaxseed oil, Sacha Inchi oil, Echium oil, and hemp oil, while sources of animal
omega-3 EPA and DHA fatty acids include fish oils, egg oil, squid oils, and krill oil. Omega-3 fatty acids are important for
normal metabolism. Mammals are unable to synthesize omega-3 fatty acids, but can obtain the shorter-chain omega-3 fatty acid
ALA through diet and use it to form the more important long-chain omega-3 fatty acids, EPA and then from EPA, the most
crucial, DHA.
DOSE
One capsule once or twice daily or as directed by the doctor.
INTRODUCTION
CAP: ENERGY 0.550 KCAL , CARBOHYDRATE 82.00 MG. 0.02% , PROTEIN 55.48 MG. 0.110% , FAT 0.00 , METHYLCOBALAMIN 1500 MCG , FOLIC ACID 400 MCG 100% , LYCOPENE (6%) 100 MCG , SPIRULINA (60% PROTEIN) 10MG , LUTEIN (10% ESTER) 1 MG. , POTASSIUM SULPHATE 1 MG. 0.028 % , VITAMIN B1 1.5 MG.100 % , VITAMIN B2 1.7 MG. 100% , VITAMIN B6 1.5MG. 75% , VITAMIN B12 5MCG 83.33 % , NICOTINAMIDE (NIACINAMIDE 20MG. 100% , CALCIUM D-PANTOTHENATE 5MG. 50% , CHROMIUM PICOLINATE 100MCG. 83.33% , VITAMIN A (AS ACETATE) 5000 I.U.100% , VITAMIN E (50%) 30 I.U.100% , VITAMIN C (COATED) 60MG. 100% , ZINC SULPHATE 15MG. 40% , CUPRIC OXIDE 1MG. 40% , MANGANESE SULPHATE 1.5 MG. 24 % , EXCIPIENTS Q.S.
FALCOBA-O: ENERGY 0.701 KCAL , PROTEIN 55.48 MG 0.11% , CARBOHYDRATE 120.00 MG 0.04% , FAT 0.00 MG , OMEGA 3 FATTY ACID 150 MG , (EPA-9%, DHA-6%) ZINC SULPHATE MONOHYDRATE 15 MG 40% , PYRIDOXINE HYDROCHLORIDE 2 MG 100% , METHYLCOBALAMIN 1500 MCG , FOLIC ACID 400 MCG 100% , EXCIPIENTS Q.S.
SYP: EACH 5 ML CONTAINS : CHOLECALCIFEROL IP (AS STABILIZED) 200 IU , PYRIDOXINE HYDROCHIORIDE IP 1MG. , NIACINAMIDE IP 15MG , CYANOCOBALAMIN IP 1MCG, ZINC (AS ZINC GLUCONATE USP) 3MG. , MANGANESE USP 0.8 MG (AS MANGANESE CHLORIDE TETRAHYDRATE) , SELENIUM (AS SODIUM SELENATE) 10MCG., LYSINE HYDROCHLORIDE USP 30MG. , IODINE (AS POTASSIUM IODIDE IP) 50MCG. , LYCOPENE (6%) 1000MCG. , CHROMIUM USP 10MCG. (AS CHROMIUM CHLORIDE HEXAHYDRATE) , INOSITOL 10MG. IN A FLAVOURED SORBITOL BASE.
DROPS: EACH 5ML CONTAINS: ENERGY 2.223 KCAL , CARBOHYDRATE 0.00 GM, SUGAR 0.500 GM , PROTEIN 0.000 GM , FAT 0.000 GM , SORBITOL 0.1 GM, ZINC SULPHATE 11 MG. 73.33% , (EQV. TO 2.5MG OF ELEMENTAL ZINC), VITAMIN A PAIMITATE 750 I.U.15.00% , VITAMIN B1 0.5 MG 33.00 % , VITAMIN B2 0.5 MG. 29.40% , VITAMIN D3 200 I.U. 50.00 % , VITAMIN B6 0.5 MG 25.00% , NICOTINAMIDE 5.0 MG 25.00% , CHOLINE CHLORIDE 3.45 MG 19.16%.
INJ: METHYLCOBALAMIN IP 1500MCG. BENZYL ALCOHO IP 2% V/V (AS PRESERVATIVE) WATER FOR INJECTION IP Q.S.
Carbohydrates are chemically made up of carbon, hydrogen and oxygen to form sachhharide groups like mono, di and poly. Carbohydrates are absorbed as monosaccharides as glucose.Fructose and galactose are also converted to glucose.
Proteins are made up of amino acids in which is essential for nutrition, growth and repair. Absorbed into blood. Proteins cannot be stored, excess protein converted to carbohydrate and fat. 23 amino acids are there 10 are essential.
Fat are fuel supply of animal kingdom. Body depot fats are mainly composed of triglycerides which are ester of fatty acid and glycerol.
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to vitamin B12, and can be used to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and differs from cyanocobalamin in that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some bacteria. It plays an important role in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin plays an important role in transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin is well transported to nerve cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin, prescribed for peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. Peripheral neuropathies- the recommended dose is 1,500 mcg/day in 3 divided doses.
Folic acid is essential for normal erythropoiesis process by exogenous administration. Folic acid is vital for the biosynthesis of purines and thymidylate of nucleic acids. Folic acid is rapidly absorbed in the proximal portion of the small intestine. After oral administration, the Cmax can be achieved within one hour. Folic acid is well-distributed in all over the body tissues and stored in hepatic tissues. Folic acid is metabolized in liver into dihydrofolate and tetrahydrofolate forms. About 90% of the administered dose is excreted via the urine.
Lycopene is a bright red carotene and carotenoid pigment and phytochemical found in tomatoes and other red fruits and vegetables. Although lycopene is chemically a carotene, it has no vitamin A activity. Lycopene is not an essential nutrient for humans, but is commonly found in the diet, mainly from dishes prepared from tomatoes. When absorbed from the stomach, lycopene is transported in the blood by various lipoproteins and accumulates in the liver, adrenal glands, and testes. Because preliminary research has shown an inverse correlation between consumption of tomatoes and cancer risk, lycopene has been considered a potential agent for prevention of some types of cancers, particularly prostate cancer.
Spirulina Spirulina is a cyanobacterium (blue-green algae) that can be consumed by humans and other animals. There are two species, Arthrospira platensis and Arthrospira maxima. Arthrospira is cultivated worldwide; used as a dietary supplement as well as a whole food; and is also available in tablet, flake and powder form. It is also used as a feed supplement in the aquaculture, aquarium and poultry industries.
Lutein is a xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. In green plants, xanthophylls act to modulate light energy and serve as non-photochemical quenching agents to deal with triplet chlorophyll (an excited form of chlorophyll), which is overproduced at very high light levels, during photosynthesis.
Potassium sulphate forms alkaline salts that are important in body processes and play an essential role in maintenance of the acid base and water balance in the body.
Vitamins- Water Soluble – B Complex & C, Fat Soluble – A,D,E & K.
Nicotinamide(Niacinamide) or PPF requirement is 15-20 mg and Deficiency causes Pellagra(Dermatitis & Pigmentation of skin).
Calcium D-Panothenate is calcium salt of pantothenic acid. Pantothenic acid, also called vitamin B5 (a B vitamin), is a water-soluble vitamin. Pantothenic acid is an essential nutrient. Animals require pantothenic acid to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. The anion is called pantothenate.
Chromium(III) picolinate is a chemical compound sold as a nutritional supplement to treat type 2 diabetes and promote weight loss. This bright-red coordination compound is derived from chromium(III) and picolinic acid. Small quantities of chromium are needed for glucose utilization by insulin in normal health, but deficiency is extremely rare and has only been observed in hospital patients on long-term defined diets. Chromium has been identified to regulate insulin by increasing the sensitivity of the insulin receptor. As such, chromium(III) picolinate has been used as a treatment for type 2 diabetes.
VitA is Retinol requirement is 5000 I.U. and deficiency causes Nyctalopia(blindness).
VitE is Alpha Tocoferol and deficiency causes not known till date.
VitC is Ascorbic acid and deficiency causes Scurvy.
Zinc Zinc is an essential mineral. In children it causes growth retardation, delayed sexual maturation, infection susceptibility, and diarrhea. Zinc stimulates the activity of about 200 enzymes, maintain healthy immune system, maintains memory, prevents premature delivery, helps AIDS patients to increase immunity, has anti-inflammatory benefits , needed for DNA synthesis , helps normal growth and development, helps sperm production and ovulation, helps in digestion of food, prevents hair loss and Alopecia, provides healthy nails, strengthen bone, helps to fight infection, helps in controlling diabetes, helps acne and wound healing, is vital in protein stnthesis, helps in carrying cabon-di-oxide from the cells. Zinc requirements Infants- 0 - 6 months: 2 milligrams per day (mg/day), 7 - 12 months: 3 mg/day /, Children: 1 - 3 years: 3 mg/day, 4 - 8 years: 5 mg/day, 9 - 13 years: 8 mg/day /Adolescents and Adults - Males age 14 and over: 11 mg/day, Females age 14 to 18 years: 9 mg/day, Females age 19 and over: 8 mg/day.
Copper daily requirement is 2 mg and deficiency not known.
Manganese is required for enzymatic activity and cholesterol synthesis.
Selenium reduces the effects of vit E deficiency, particularly liver necrosis and muscular dystrophy.
Diabetic neuropathies are nerve damaging disorders associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves in addition to macrovascular conditions that can culminate in diabetic neuropathy.
Antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons or hydrogen from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. In turn, these radicals can start chain reactions. When the chain reaction occurs in a cell, it can cause damage or death to the cell. Antioxidants terminate these chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves.
Essential vitamins is a nutrient required for normal physiological function that cannot be synthesized by the body, and thus must be obtained from a dietary source.
Minerals Minerals are inorganic substances playing important role in body mechanism – sodium, potassium, iron, phosphorus, magnesium and sulphur.
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
Myelination is the production of the myelin sheath. Myelin is a fatty white substance that surrounds the axon of some nerve cells, forming an electrically insulating layer. It is essential for the proper functioning of the nervous system.
Homocystein is a non-protein α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH2-). Homocysteine can be recycled into methionine or converted into cysteine with the aid of certain B-vitamins. A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury.
Omega-3 fatty acids are of three types involved in human physiology are α-linolenic acid (ALA) (found in plant oils), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) (both commonly found in marine oils). Marine algae and phytoplankton are primary sources of omega-3 fatty acids. Common sources of plant oils containing the omega-3 ALA fatty acid include walnut, edible seeds, clary sage seed oil, algal oil, flaxseed oil, Sacha Inchi oil, Echium oil, and hemp oil, while sources of animal omega-3 EPA and DHA fatty acids include fish oils, egg oil, squid oils, and krill oil. Omega-3 fatty acids are important for normal metabolism. Mammals are unable to synthesize omega-3 fatty acids, but can obtain the shorter-chain omega-3 fatty acid ALA through diet and use it to form the more important long-chain omega-3 fatty acids, EPA and then from EPA, the most crucial, DHA.
One capsule once or twice daily or as directed by the doctor.