EACH CAPSULES CONTAINS: PREGABALIN I.P. 75 MG. (IN SUSTAINED RELEASE FROM) METHYLCOBALAMIN I.P. 1500MCG. EXCIPIENTS Q.S.
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial
seizures. It has also been found effective for generalized anxiety disorder. Pregabalin is effective at treating
chronic pain in disorders such as fibromyalgia and spinal cord injury. It is considered to have a low potential
for abuse. Pregabalin is available in 25, 50, 75, 100, 150, 200, 225, and 300 mg capsules .The maximum daily
recommended dose for pregabalin is 600 mg. Dosages must be monitored and increases should be based on patient's
tolerance. Like gabapentin, Pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependant calcium
channel in the central nervous system. Pregabalin decreases the release of neurotransmitters including glutamate,
noradrenaline, substance P and calcitonin gene-related peptide. Pregabalin is rapidly absorbed when administered
on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin is an anticonvulsant
and neuropathic pain agent, prescribed for partial seizures, management of postherpetic neuralgia (nerve pain
caused by the varicella zoster virus), management of fibromyalgia( a condition where the patient has muscle and
connective tissue pain).
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from
cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral
cobalt(III) centre and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to
vitamin B12, and can be used to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy,
diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and
differs from cyanocobalamin in that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some
bacteria. It plays an important role in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin
plays an important role in transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin
is well transported to nerve cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin,
prescribed for peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis.
Peripheral neuropathies- the recommended dose is 1,500 mcg/day in 3 divided doses.
INDICATIONS
Peripheral Neuropathy is damage to nerves of the peripheral nervous system, which may be caused either by diseases
of or trauma to the nerve or the side-effects of systemic illness. The four patterns of peripheral neuropathy are
polyneuropathy, mononeuropathy, mononeuritis multiplex and autonomic neuropathy.
Drug induced Neuropathy is damage to nerves of the peripheral nervous system, which may be caused either by diseases
of or trauma to the nerve or the side-effects of systemic illness due to varieties of medication.
Diabetic Neuropathy occurs in the patients when blood sugar levels are too high. Over time, this can damage the
covering on nerves or the blood vessels that bring oxygen to nerves. Damaged nerves may stop sending messages, or may
send messages slowly or at the wrong times. This damage is called diabetic neuropathy. About half of people with diabetes
get it.
Bell’s Palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the facial nerve)
that results in the inability to control facial muscles on the affected side.
NOTE
Neurotransmitters, also known as special messengers, are endogenous chemicals that enable neurotransmission. They
transmit signals across a chemical synapse, such as a neuromuscular junction, from one neuron (nerve cell) to another
"target" neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the
synaptic cleft, where they are received by receptors on the target cells.
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous
as voltage-dependent calcium channel. Ectopic mean abnormal.
Ectopic mean abnormal.
Sensory neurones are nerves that transmit sensory information sight, sound, feeling, etc.
Pregabalin Vs gabapentin gabapentin as both are anticonvulsants used to treat epileptic seizures and a variety of
other medical conditions. As medications that are very similar, they do have their differences. The main difference is
that pregabalin is the more potent of the two medications. Other differences between the two medications are that the
body absorbs pregabalin at a faster rate, and pregabalin also causes less dose-dependent side effects than gabapentin.
Since pregabalin is more potent than gabapentin, it takes a smaller dose of pregabalin to equal the same level of
potency in a dose of gabapentin. This means a patient would take a lesser dose of pregabalin as opposed to a bigger dose
of gabapentin. The absorption properties of pregabalin also work to its advantage as it ensures a steadier intake of the
medication. Pregabalin and gabapentin both cause side effects but gabapentin tends to cause more side effects that depend
on the dosage of the medication. Of course, side effects also depend on a patient’s specific condition as well.
DOSE
One tablet once daily or as directed by the doctor.
INTRODUCTION
EACH CAPSULES CONTAINS: PREGABALIN I.P. 75 MG. (IN SUSTAINED RELEASE FROM) METHYLCOBALAMIN I.P. 1500MCG. EXCIPIENTS Q.S.
Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures. It has also been found effective for generalized anxiety disorder. Pregabalin is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury. It is considered to have a low potential for abuse. Pregabalin is available in 25, 50, 75, 100, 150, 200, 225, and 300 mg capsules .The maximum daily recommended dose for pregabalin is 600 mg. Dosages must be monitored and increases should be based on patient's tolerance. Like gabapentin, Pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependant calcium channel in the central nervous system. Pregabalin decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide. Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin is an anticonvulsant and neuropathic pain agent, prescribed for partial seizures, management of postherpetic neuralgia (nerve pain caused by the varicella zoster virus), management of fibromyalgia( a condition where the patient has muscle and connective tissue pain).
Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin a form of vitamin B12. It differs from cyanocobalamin in that the cyano at the cobalt is replaced with a methyl group.Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. methylcobalamin is equivalent physiologically to vitamin B12, and can be used to prevent or treat pathology arising from a lack of vitamin B in peripheral neuropathy, diabetic neuropathy, and as a preliminary treatment for amyotrophic lateral sclerosis. It is a form of vitamin B12 and differs from cyanocobalamin in that the cyanide is replaced by a methyl group. Methylcobalamin is produced by some bacteria. It plays an important role in the environment. Methylcobalamin is a kind of endogenous co enzyme B12. Mecobalamin plays an important role in transmethylation as a co enzyme in the synthesis of methionine from homocysteine . Mecobalamin is well transported to nerve cell organnells and promotes nucleic acid and protein synthesis. This medication is a cobalamin, prescribed for peripheral neuropathy, megaloblastic anaemia, and as a preliminary treatment for amyotrophic lateral sclerosis. Peripheral neuropathies- the recommended dose is 1,500 mcg/day in 3 divided doses.
Peripheral Neuropathy is damage to nerves of the peripheral nervous system, which may be caused either by diseases of or trauma to the nerve or the side-effects of systemic illness. The four patterns of peripheral neuropathy are polyneuropathy, mononeuropathy, mononeuritis multiplex and autonomic neuropathy.
Drug induced Neuropathy is damage to nerves of the peripheral nervous system, which may be caused either by diseases of or trauma to the nerve or the side-effects of systemic illness due to varieties of medication.
Diabetic Neuropathy occurs in the patients when blood sugar levels are too high. Over time, this can damage the covering on nerves or the blood vessels that bring oxygen to nerves. Damaged nerves may stop sending messages, or may send messages slowly or at the wrong times. This damage is called diabetic neuropathy. About half of people with diabetes get it.
Bell’s Palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the facial nerve) that results in the inability to control facial muscles on the affected side.
Neurotransmitters, also known as special messengers, are endogenous chemicals that enable neurotransmission. They transmit signals across a chemical synapse, such as a neuromuscular junction, from one neuron (nerve cell) to another "target" neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the synaptic cleft, where they are received by receptors on the target cells.
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel. Ectopic mean abnormal.
Ectopic mean abnormal.
Sensory neurones are nerves that transmit sensory information sight, sound, feeling, etc.
Pregabalin Vs gabapentin gabapentin as both are anticonvulsants used to treat epileptic seizures and a variety of other medical conditions. As medications that are very similar, they do have their differences. The main difference is that pregabalin is the more potent of the two medications. Other differences between the two medications are that the body absorbs pregabalin at a faster rate, and pregabalin also causes less dose-dependent side effects than gabapentin. Since pregabalin is more potent than gabapentin, it takes a smaller dose of pregabalin to equal the same level of potency in a dose of gabapentin. This means a patient would take a lesser dose of pregabalin as opposed to a bigger dose of gabapentin. The absorption properties of pregabalin also work to its advantage as it ensures a steadier intake of the medication. Pregabalin and gabapentin both cause side effects but gabapentin tends to cause more side effects that depend on the dosage of the medication. Of course, side effects also depend on a patient’s specific condition as well.
One tablet once daily or as directed by the doctor.