Fexofenadine Hydrochloride or Fexofenadine is sometimes called a third generation antihistamine because it is less able to pass the blood brain barrier and cause sedation, compared to first generation antihistamines. Fexofenadine is a selectively peripheral H1blocker. Blockage prevents the activation of the H1 receptors by histamine, preventing the symptoms associated with allergies from occurring. After oral application, maximum plasma concentrations are reached after two to three hours. Fexofenadine should not be taken with a high fat meal. Distribution of Fexofenadine is 60-70% bound to plasma proteins, mostly albumin. Only 5% fexopfenadine is metabolized in the liver. The elimination of fexofenadine is eliminated unchanged via the feces (80%) and urine.
Montelukust Sodium or Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast is usually taken once a day with or without food. Montelukast is a CysLT1 antagonist. It blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific mechanism of action, it does not interact with other asthma medications such as theophylline. The Mont in Montelukast stands for Montreal, the place where Merck developed the drug.
LEVOCUS Tab
EACH FILM COATED CONTAINS: LEVOCETRIZINE HYDROCHLORIDE I.P. 5 MG. MONTELUKAST SODIUM I.P. EQV. TO MONTELUKAST 10 MG. EXCIPIENTS Q.S.
Levocetirizine (as levocetirizine dihydrochloride) is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer or optical isomer ( same molecular formula with a different chemical structure) of cetirizine. It is the R-enantiomer of the cetirizine racemate. Levocetirizine is an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever. It does not prevent the actual release of histamine from mast cells.
Montelukust Sodium or Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast is usually taken once a day with or without food. Montelukast is a CysLT1 antagonist. It blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction and results in less inflammation. Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific mechanism of action, it does not interact with other asthma medications such as theophylline. The Mont in Montelukast stands for Montreal, the place where Merck developed the drug.
Asthma is a common long term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath.
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little or no problem in most people. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine.
β2 adrenergic receptor agonists, also known as adrenergic β2 receptor agonists, are a class of drugs that act on the β2adrenergic receptor. Like other β adrenergic agonists, they cause smooth muscle relaxation. β2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages. They are primarily used to treat asthma and other pulmonary disorders, like COPD.
One tablet once daily or as directed by the doctor.