Azithromycin is an azalide, a subclass of macrolide antibiotics. It retains the spectrum of activity of erythromycin against gram+ & gram- pathogens and has increased activity against many gram- and atypical micro organisms. It has greater acid stability than erythromycin and its gastro intestinal tolerance is better than that of erythromycin. It acts by interfering with microbial protein synthesis by binding to the 50S ribosomal sub-unit thus inhibits translation of mRNA. In recent years, it has been used primarily to prevent bacterial infections in infants and those weaker immune systems. It is also effective against certain sexually transmitted infections, such as nongonococcal urethritis, chlamydia, and cervicitis. Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Chlamydia pneumoniae, Chlamydia trachomatis, Eikenella corrodens, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Mycobacterium chelonae, Mycoplasma fermentans, Neisseria gonorrhoeae and Ureaplasma urealyticum are generally susceptible to azithromycin dihydrate, while Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes are resistant to azithromycin dihydrate. Furthermore, some Brevibacterium spp., Corynebacterium amycolatum, Haemophilus influenzae and Mycobacterium abscessus have developed resistance to azithromycin dihydrate to varying degrees.
INDICATIONS
Lower respiratory tract infection (LRTI), while often used as a synonym for pneumonia, can also be applied to other types of infection including lung abscess and acute bronchitis. The two most common are bronchitis and pneumonia. Influenza affects both the upper and lower respiratory tracts.
Skin and soft tissue infection (SSTI) also referred to as Skin and skin structure infection (SSSI) or acute bacterial skin and skin structure infection (ABSSSI), is an infection of skin and associated soft tissues (such as loose connective tissue and mucous membranes). The pathogen involved is usually a bacterial species. Such infections often requires treatment by antibiotics. Two types are complicated skin and skin structure infection (cSSSI) and uncomplicated skin and skin structure infection (uSSSI). "Uncomplicated" SSSIs included simple abscesses, impetiginous lesions, furuncles, and cellulitis. "Complicated" SSSIs included infections either involving deeper soft tissue or requiring significant surgical intervention, such as infected ulcers, burns, and major abscesses or a significant underlying disease state that complicates the response to treatment. Superficial infections or abscesses in an anatomical site, such as the rectal area, where the risk of anaerobic or gram-negative pathogen involvement is higher, should be considered complicated infections. The two categories had different regulatory approval requirements. The uncomplicated category (uSSSI) is normally only caused by Staphylococcus aureus and Streptococcus pyogenes, whereas the complicated category (cSSSI) might also be caused by a number of other pathogens.
Urinary Tract Infection Infection is urinary tract infection (UTI) is an infection that affects part of the urinary tract When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. The most common cause of infection is Escherichia coli, though other bacteria or fungi may rarely be the cause.
Intra abdominal infection (IAI) is a group of infections that occur within the abdominal cavity. They vary from appendicitis to fecal peritonitis. Risk of death despite treatment is often high.
Sinus is a sac or cavity in any organ or tissue Types of Sinuses are - Paranasal sinuses, air cavities in the cranial bones, especially those near the nose, including-Maxillary sinus(is the largest of the paranasal sinuses, under the eyes, in the maxillary bones),Frontal sinus(superior to the eyes, in the frontal bone, which forms the hard part of the forehead),Ethmoid sinus(formed from several discrete air cells within the ethmoid bone between the eyes and under the nose),Sphenoidal sinus(in the sphenoid bone at the center of the skull base under the pituitary gland),Anal sinuses(the furrows which separate the columns in the rectum),Dural venous sinuses(venous channels found between layers of dura mater in the brain).
Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms. Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may include fever, headaches, poor sense of smell, sore throat, and cough.
NOTE
Gram staining or Gram stain, also called Gram's method, is a method of staining used to differentiate bacterial species into two large groups (gram-positive and gram-negative). The name comes from the Danish bacteriologist Hans Christian Gram, who developed the technique. Gram staining differentiates bacteria by the chemical and physical properties. Gram-positive bacteria retain the crystal violet dye while the Gram-negative bacteria do not.
DOSE
One tablet once daily for 5 -10 days or as directed by the doctor.
INTRODUCTION
AZITHROMYCIN DIHYDRATE I.P. EQV. TO ANHYDROUS AZITHROMYCIN 250MG. EXCIPIENTS Q.S
AZITHROMYCIN DIHYDRATE I.P. EQV. TO ANHYDROUS AZITHROMYCIN 500 MG. EXCIPIENTS Q.S.
AZITHROMYCIN DIHYDRATE I.P. EQV. TO ANHYDROUS AZITHROMYCIN 200 MG/5ML. EXCIPIENTS Q.S.
Azithromycin is an azalide, a subclass of macrolide antibiotics. It retains the spectrum of activity of erythromycin against gram+ & gram- pathogens and has increased activity against many gram- and atypical micro organisms. It has greater acid stability than erythromycin and its gastro intestinal tolerance is better than that of erythromycin. It acts by interfering with microbial protein synthesis by binding to the 50S ribosomal sub-unit thus inhibits translation of mRNA. In recent years, it has been used primarily to prevent bacterial infections in infants and those weaker immune systems. It is also effective against certain sexually transmitted infections, such as nongonococcal urethritis, chlamydia, and cervicitis. Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Chlamydia pneumoniae, Chlamydia trachomatis, Eikenella corrodens, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis, Mycobacterium chelonae, Mycoplasma fermentans, Neisseria gonorrhoeae and Ureaplasma urealyticum are generally susceptible to azithromycin dihydrate, while Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes are resistant to azithromycin dihydrate. Furthermore, some Brevibacterium spp., Corynebacterium amycolatum, Haemophilus influenzae and Mycobacterium abscessus have developed resistance to azithromycin dihydrate to varying degrees.
Lower respiratory tract infection (LRTI), while often used as a synonym for pneumonia, can also be applied to other types of infection including lung abscess and acute bronchitis. The two most common are bronchitis and pneumonia. Influenza affects both the upper and lower respiratory tracts.
Skin and soft tissue infection (SSTI) also referred to as Skin and skin structure infection (SSSI) or acute bacterial skin and skin structure infection (ABSSSI), is an infection of skin and associated soft tissues (such as loose connective tissue and mucous membranes). The pathogen involved is usually a bacterial species. Such infections often requires treatment by antibiotics. Two types are complicated skin and skin structure infection (cSSSI) and uncomplicated skin and skin structure infection (uSSSI). "Uncomplicated" SSSIs included simple abscesses, impetiginous lesions, furuncles, and cellulitis. "Complicated" SSSIs included infections either involving deeper soft tissue or requiring significant surgical intervention, such as infected ulcers, burns, and major abscesses or a significant underlying disease state that complicates the response to treatment. Superficial infections or abscesses in an anatomical site, such as the rectal area, where the risk of anaerobic or gram-negative pathogen involvement is higher, should be considered complicated infections. The two categories had different regulatory approval requirements. The uncomplicated category (uSSSI) is normally only caused by Staphylococcus aureus and Streptococcus pyogenes, whereas the complicated category (cSSSI) might also be caused by a number of other pathogens.
Urinary Tract Infection Infection is urinary tract infection (UTI) is an infection that affects part of the urinary tract When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. The most common cause of infection is Escherichia coli, though other bacteria or fungi may rarely be the cause.
Intra abdominal infection (IAI) is a group of infections that occur within the abdominal cavity. They vary from appendicitis to fecal peritonitis. Risk of death despite treatment is often high.
Sinus is a sac or cavity in any organ or tissue Types of Sinuses are - Paranasal sinuses, air cavities in the cranial bones, especially those near the nose, including-Maxillary sinus(is the largest of the paranasal sinuses, under the eyes, in the maxillary bones),Frontal sinus(superior to the eyes, in the frontal bone, which forms the hard part of the forehead),Ethmoid sinus(formed from several discrete air cells within the ethmoid bone between the eyes and under the nose),Sphenoidal sinus(in the sphenoid bone at the center of the skull base under the pituitary gland),Anal sinuses(the furrows which separate the columns in the rectum),Dural venous sinuses(venous channels found between layers of dura mater in the brain).
Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms. Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may include fever, headaches, poor sense of smell, sore throat, and cough.
Gram staining or Gram stain, also called Gram's method, is a method of staining used to differentiate bacterial species into two large groups (gram-positive and gram-negative). The name comes from the Danish bacteriologist Hans Christian Gram, who developed the technique. Gram staining differentiates bacteria by the chemical and physical properties. Gram-positive bacteria retain the crystal violet dye while the Gram-negative bacteria do not.
One tablet once daily for 5 -10 days or as directed by the doctor.