EACH TABLET CONTAINS: AMOXYCILLIN TRIHYDRATE I.P. EQV. TO AMOXYCILLIN 500MG + POTASSIUM CLAVULANATE I.P. (AS POTASSIUM CLAVULANATE
DILUTED I.P.) EQV. TO CLAVULANIC ACID 125MG +Lactobacillus 60 thousand spores.
Amoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections
caused by susceptible microorganisms. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria,
which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often
combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility
to β-lactamase resistance. This drug acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage
between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive
and Gram-negative bacteria.
Potassium clavulanate is a salt of Clavulanic acid is a mechanism-based β-lactamase inhibitor combined
with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance
in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. In its most common form, the potassium
salt potassium clavulanate is combined with - amoxicillin , ticarcillin. Clavulanic acid has negligible intrinsic
antimicrobial activity, despite sharing the β-lactam ring that is characteristic of β-lactam antibiotics. However,
the similarity in chemical structure allows the molecule to interact with the enzyme β-lactamase secreted by certain
bacteria to confer resistance to β-lactam antibiotics. Clavulanic acid is a suicide inhibitor, covalently bonding to a
serine residue in the active site of the β-lactamase of bacteria. This restructures the clavulanic acid molecule, creating
a much more reactive species that is attacked by another aminoacid in the active site, permanently inactivating it, and
thus inactivating the enzyme. This inhibition restores the antimicrobial activity of β-lactam antibiotics against
lactamase-secreting resistant bacteria.
Lactobasillus Lactobacillus is also in some fermented foods like yogurt and in dietary supplements. Lactobacillus
is taken by mouth to treat and prevent diarrhea, including infectious types such as rotaviral diarrhea
in children and traveler's diarrhea.
INDICATIONS
Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis media
(AOM) and otitis media with effusion (OME). Chronic suppurative otitis media (CSOM) is middle ear inflammation.
Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms.
Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may
include fever, headaches, poor sense of smell, sore throat, and cough.
Skin and soft tissue infection (SSTI) ) also referred to as Skin and skin structure infection (SSSI) or acute
bacterial skin and skin structure infection (ABSSSI), is an infection of skin and associated soft tissues (such as loose
connective tissue and mucous membranes). The pathogen involved is usually a bacterial species. Such infections often
requires treatment by antibiotics. Two types are complicated skin and skin structure infection (cSSSI) and uncomplicated
skin and skin structure infection (uSSSI). "Uncomplicated" SSSIs included simple abscesses, impetiginous lesions,
furuncles, and cellulitis. "Complicated" SSSIs included infections either involving deeper soft tissue or requiring
significant surgical intervention, such as infected ulcers, burns, and major abscesses or a significant underlying disease
state that complicates the response to treatment. Superficial infections or abscesses in an anatomical site, such as the
rectal area, where the risk of anaerobic or gram-negative pathogen involvement is higher, should be considered complicated
infections. The two categories had different regulatory approval requirements. The uncomplicated category (uSSSI) is
normally only caused by Staphylococcus aureus and Streptococcus pyogenes, whereas the complicated category (cSSSI)
might also be caused by a number of other pathogens
RTI or Respiratory tract infection refers to any of a number of infectious diseases involving the respiratory tract.
An infection of this type is normally further classified as an upper respiratory tract infection (URI or URTI) or a lower
respiratory tract infection (LRI or LRTI). Lower respiratory infections, such as pneumonia, tend to be far more serious
conditions than upper respiratory infections, such as the common cold.
Urinary Tract Infection is urinary tract infection (UTI) is an infection that affects part of the urinary tract When
it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary
tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination,
frequent urination, and feeling the need to urinate despite having an empty bladder. The most common cause of infection is
Escherichia coli, though other bacteria or fungi may rarely be the cause.
NOTE
Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria, which causes the sexually transmitted
disease chancroid, a major cause of genital ulceration in developing countries characterized by painful sores on the
genitalia.
INTRODUCTION
EACH TABLET CONTAINS: AMOXYCILLIN TRIHYDRATE I.P. EQV. TO AMOXYCILLIN 500MG + POTASSIUM CLAVULANATE I.P. (AS POTASSIUM CLAVULANATE DILUTED I.P.) EQV. TO CLAVULANIC ACID 125MG +Lactobacillus 60 thousand spores.
Amoxicillin is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid, a β-lactamase inhibitor. This increases effectiveness by reducing its susceptibility to β-lactamase resistance. This drug acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria.
Potassium clavulanate is a salt of Clavulanic acid is a mechanism-based β-lactamase inhibitor combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. In its most common form, the potassium salt potassium clavulanate is combined with - amoxicillin , ticarcillin. Clavulanic acid has negligible intrinsic antimicrobial activity, despite sharing the β-lactam ring that is characteristic of β-lactam antibiotics. However, the similarity in chemical structure allows the molecule to interact with the enzyme β-lactamase secreted by certain bacteria to confer resistance to β-lactam antibiotics. Clavulanic acid is a suicide inhibitor, covalently bonding to a serine residue in the active site of the β-lactamase of bacteria. This restructures the clavulanic acid molecule, creating a much more reactive species that is attacked by another aminoacid in the active site, permanently inactivating it, and thus inactivating the enzyme. This inhibition restores the antimicrobial activity of β-lactam antibiotics against lactamase-secreting resistant bacteria.
Lactobasillus Lactobacillus is also in some fermented foods like yogurt and in dietary supplements. Lactobacillus is taken by mouth to treat and prevent diarrhea, including infectious types such as rotaviral diarrhea in children and traveler's diarrhea.
Otitis media is a group of inflammatory diseases of the middle ear. The two main types are acute otitis media (AOM) and otitis media with effusion (OME). Chronic suppurative otitis media (CSOM) is middle ear inflammation.
Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms. Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may include fever, headaches, poor sense of smell, sore throat, and cough.
Skin and soft tissue infection (SSTI) ) also referred to as Skin and skin structure infection (SSSI) or acute bacterial skin and skin structure infection (ABSSSI), is an infection of skin and associated soft tissues (such as loose connective tissue and mucous membranes). The pathogen involved is usually a bacterial species. Such infections often requires treatment by antibiotics. Two types are complicated skin and skin structure infection (cSSSI) and uncomplicated skin and skin structure infection (uSSSI). "Uncomplicated" SSSIs included simple abscesses, impetiginous lesions, furuncles, and cellulitis. "Complicated" SSSIs included infections either involving deeper soft tissue or requiring significant surgical intervention, such as infected ulcers, burns, and major abscesses or a significant underlying disease state that complicates the response to treatment. Superficial infections or abscesses in an anatomical site, such as the rectal area, where the risk of anaerobic or gram-negative pathogen involvement is higher, should be considered complicated infections. The two categories had different regulatory approval requirements. The uncomplicated category (uSSSI) is normally only caused by Staphylococcus aureus and Streptococcus pyogenes, whereas the complicated category (cSSSI) might also be caused by a number of other pathogens
RTI or Respiratory tract infection refers to any of a number of infectious diseases involving the respiratory tract. An infection of this type is normally further classified as an upper respiratory tract infection (URI or URTI) or a lower respiratory tract infection (LRI or LRTI). Lower respiratory infections, such as pneumonia, tend to be far more serious conditions than upper respiratory infections, such as the common cold.
Urinary Tract Infection is urinary tract infection (UTI) is an infection that affects part of the urinary tract When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. The most common cause of infection is Escherichia coli, though other bacteria or fungi may rarely be the cause.
Haemophilus ducreyi is a fastidious gram-negative coccobacillus bacteria, which causes the sexually transmitted disease chancroid, a major cause of genital ulceration in developing countries characterized by painful sores on the genitalia.
Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus pneumonia, Streptococcus pyogenes, Viridans group Streptococcus.
Gram-negative bacteria Enterobacter species, Escherichia coli, Haemophilus influenza, Klebsiella species, Moraxella catarrhalis Eikenella corrodens, Proteus mirabilis
Anaerobic Bacteria Bacteroides species including Bacteroides fragilis, Fusobacterium species, Peptostreptococcus species
One tablet twice daily for 5-10 days or as directed by the doctor.